Products
Basic information

Chinese name: N-(3-chloropropyl)morpholine

Chinese Alias: 3-Morpholinopropyl chloride; Gefitinib intermediate 8; 4-(3-Chloropropyl)morpholine; 4-(3-Chloropropyl)morpholine;

English name: 4-(3-Chloropropyl)morpholine

English Alias: 4-(3-chloropropyl)morpholine

CAS No.: 7357-67-7

Molecular formula: C7H14ClNO

Molecular weight: 163.64500

Precise mass: 163.07600

PSA: 12.47000

LogP: 0.88540

Physical and chemical properties

Appearance and properties: Light yellow to colorless liquid

Density: 1.062 g/cm3

Boiling Point: 227.1oC at 760 mmHg

Flash point: 91.2oC

Storage conditions: -20oC Freezer, Under Inert Atmosphere

Hazard Overview

GHS Classification
Physical Hazards Not Classified
Health Hazards
Skin corrosion/irritation Class 2
Severe damage/eye irritation Class 2A
Environmental hazards not classified
GHS Labeling Elements
Icon or hazard symbol
Signal word warning
Hazard description causes skin irritation
Causes severe eye irritation
Precautionary statements
Wash hands thoroughly after handling [Precaution].
Wear protective gloves/goggles/protective mask.
[FIRST AID] Eye contact: Wash carefully with water for several minutes. If convenient and easy to handle, remove contact lenses. Continue rinsing.
Eye contact: Seek medical attention/consultation
Skin contact: Wash gently with plenty of soap and water.
If skin irritation: Seek medical attention/consultation.
Remove contaminated clothing and wash before reuse.
Module 3. Ingredient/Composition Information

Single substance/mixture Single substance
Chemical name (Chinese name): 4-(3-chloropropyl)morpholine
Percentage: >98.0% (GC)(T)
CAS Code: 7357-67-7
Common name: 3-Morpholinopropyl Chloride
4-(3-Chloropropyl)morpholine Modification No.: 6
Module 3. Ingredient/composition information

Molecular Formula: C7H14ClNO
Module 4. First Aid Measures

Inhalation: Move victim to fresh air, keep breathing open and rest. If unwell, seek medical attention/consultation.
Skin Contact: Immediately remove/remove all contaminated clothing. Wash gently with plenty of soap and water.
If skin irritation or rash occurs: Seek medical attention/consultation.
EYE CONTACT: Wash carefully with water for several minutes. If convenient and easy to handle, remove contact lenses. Continue washing.
If eye irritation: Seek medical attention/consultation.
INGESTION: If discomfort occurs, seek medical attention/consultation. Rinse mouth.
Emergency responder protection: Rescuers need to wear personal protective equipment, such as rubber gloves and airtight goggles.
Module 5. Fire Fighting Measures

Suitable extinguishing agents: dry powder, foam, fog water, carbon dioxide
Unsuitable extinguishing agents: stick water
Special hazards: Caution, burning or decomposition at high temperatures may produce toxic smoke.
Specific method: Extinguish the fire from upwind, choose the appropriate extinguishing method according to the surrounding environment.
Non-relevant personnel should evacuate to a safe place.
Once the surrounding area is on fire: If safe, remove removable containers.
Special protective gear for firefighters: Always wear personal protective equipment when extinguishing a fire.
Module 6. Spill Response

Personal protective measures, protective gear, use personal protective equipment. Keep away from the spill/leak and upwind. Ensure adequate ventilation.
Emergency measures: Spill area should be enclosed with safety belts, etc., to control access by non-relevant personnel.
Environmental measures: Prevent entry into sewers.
Methods and materials for containment and cleaning: Absorb the spill with a suitable absorbent (e.g., old cloth, dry sand, earth, sawdust). In the event of a large spill, dike and control.
Control. Attachments or collections should be immediately disposed of in accordance with appropriate laws and regulations.
Module 7: Handling and Storage

Disposal
Technical measures: Handle in a well-ventilated area. Wear appropriate protective equipment. Prevent fumes from being generated. Wash hands and face thoroughly after handling.
and face.
Caution: If vapors or aerosols are generated, use ventilation and local exhaust.
Handling and disposal precautions: Avoid contact with skin, eyes and clothing.
Storage
Storage conditions: Keep container airtight. Refrigerated storage.
Store in an inert gas atmosphere.
Store away from incompatible materials such as oxidizing agents.
Heat sensitive, gas sensitive
Packaging materials: according to the law.
Module 8. Exposure control and individual protection

Engineering controls: Install closed systems or local exhaust systems where possible and operators must not come into direct contact. Also install showers and eye washers.
Eye washers.
Personal protective equipment
Respiratory protection: Gas mask. In accordance with local and government regulations.
Hand protection: protective gloves.
Eye protection: Safety goggles. Mask, if required.
Skin and body protection: Protective clothing. Protective boots, if required.
4-(3-chloropropyl)morpholine Modification No.: 6
Module 9. Physical and Chemical Properties

Liquid
Appearance (20°C).
Appearance: Clear
Color: Colorless – slightly light yellow
Odor: No data available
pH:No data available
Melting point: no data available
Boiling point/boiling range 115 °C/3.3 kPa
Flash point: no data available
Explosive properties
Lower explosion limit: no data available
Upper explosion limit: no information available
Density: 1.08
Solubility.
[water] no information available
[other solvents] no information available
Module 10. Stability and reactivity

Chemical Stability: Generally stable.
Potential for hazardous reactions: No particular reactivity reported.
Substances to be avoided oxidizing agents
Hazardous Decomposition Products: Carbon Monoxide, Carbon Dioxide, Nitrogen Oxides (NOx), Hydrogen Chloride
Module 11. Toxicological information

Acute toxicity: ivn-mus LD50:104 mg/kg
Skin corrosion or irritation: No information available
Severe damage or irritation to eyes: No information available
Germ cell mutagenicity: no information available
Carcinogenicity.
IARC = no information available
NTP = no information available
Reproductive toxicity: No information available
RTECS number: QE0488000
Module 12. ecological information

Ecotoxicity.
Fish: No information available
Crustaceans: No information available
Algae: No information available
Residual / Degradability: No information available
Potential bioaccumulation (BCF): No information available
Mobility in Soil
log water partition coefficient: not available
Soil absorption coefficient (Koc): not available
Henry’s law not available
constant(PaM3/mol):
Module 13. Disposal

If possible, recycle for disposal. Consult local regulatory authorities. Incineration in a chemical incinerator equipped with an afterburner and scrubber is recommended. For disposal, please observe
Observe all national, regional and local regulations.
4-(3-chloropropyl)morpholine Revision No.: 6
Module 14. Transport Information

UN Classification: Not consistent with UN classification standards
UN Number: Not listed
Module 15. Regulatory Information

Regulations on Safe Management of Hazardous Chemicals (issued by the State Council on January 26, 2002, amended on February 16, 2011): Addresses the safe use, production, storage, transportation, handling and other aspects of hazardous chemicals.
The Regulations on the Safety Management of Hazardous Chemicals (issued by the State Council on January 26, 2002 and amended on February 16, 2011): The regulations on the safe use, production, storage, transportation, loading and unloading of hazardous chemicals are made accordingly.

Storage and transportation.
Should be sealed and stored in a dry, cool and ventilated warehouse

Package.
200KG/drum Storage: It is recommended to store in dry and cool area with proper ventilation.
Please fasten the lid as soon as possible after the original packaging to prevent the mixing of other substances such as water and other substances from affecting the product performance.
Do not inhale dust and avoid skin and mucous membrane contact. Smoking, eating and drinking are prohibited in the workplace. After work, shower and change clothes.
Store contaminated clothes separately and wash them before use. Maintain good hygiene habits.