Products
Basic information

Chinese name: 4-(3-Hydroxypropyl)morpholine

Chinese Alias: 3-(4-Morpholinyl)-1-propanol; 3-Morpholinosubstituted-1-propanol; 3-Morpholinosubstituted-propanol;

English name: 4-(3-Hydroxypropyl)morpholine

English Alias: 3-(4-Morpholinyl)-1-propanol,3-Morpholinopropanol; 4-(3-Hydroxypropyl)Morpholine; 3-Morpholinopropanol; 3-Morpholino-1-propanol; 3-morpholin-4-ylpropan-1-ol;

CAS No.: 4441-30-9

Molecular formula: C7H15NO2

Molecular weight: 145.19900

Precise mass: 145.11000

PSA: 32.70000

Physical and chemical properties

Density: 1.049 g/mL at 25 °C(lit.)

Boiling point: 240-241 °C(lit.)

Flash point: 185 °F

Refractive index: n20/D 1.4770(lit.)

Module 1. Chemicals

1.1 Product identifier
4-(3-Hydroxypropyl)morpholine
Product name
1.2 Other methods of identification
3-Morpholinopropanol
3-(4-Morpholinyl)-1-propanol
1.3 Relevant identified uses and suggested unsuitable uses of the substance or mixture
For research and development only. Not for pharmaceutical, domestic or other use.
Module 2. Hazard overview

2.1 GHS-Classification
Flammable liquids (category 4)
Skin corrosion (Category 1B)
Serious eye injury (Category 1)
2.2 GHS Marking Elements, including Precautionary Statements
Pictograms
Warning word hazard
Hazard statement
H227 Flammable liquid
H314 Causes severe skin burns and eye damage.
Warning Statement
Precautions
P210 Keep away from heat sources, sparks, open flames and hot surfaces. – Smoking is prohibited.
P264 Clean skin thoroughly after handling.
P280 Wear protective gloves/protective clothing/goggles/face shield.
Accident Response
P301 + P330 + P331 If swallowed: rinse mouth, do not induce vomiting.
P303 + P361 + P353 If skin (or hair) contact: Remove/remove all soiled clothing immediately and wash skin/shower with water.
Bath.
P304 + P340 If aspiration: Move patient to fresh air and rest in a comfortable breathing position.
P305 + P351 + P338 If contact with eyes, rinse slowly and gently with water for several minutes. If contact lenses are worn and can be easily removed
If contact lenses are worn and can be easily removed, remove contact lenses and continue flushing.
P310 Call a poison control center or physician immediately.
P321 Specific disposal (see first aid instructions provided on this label).
P363 Wash soiled clothing before reuse.
P370 + P378 In case of fire: Use dry sand, dry chemicals or alcohol-resistant foam to extinguish the fire.
Safe storage
P403 + P235 Keep cool and store in a well ventilated area.
P405 must be stored under lock and key.
Disposal
P501 Dispose of contents/container to an approved waste disposal facility.
2.3 Other Hazards – None
Module 3: Composition/Composition Information

3.1 Substance
3-Morpholinopropanol
Synonyms
3-(4-Morpholinyl)-1-propanol
: C7H15NO2
Molecular formula
: 145.2 g/mol
Molecular weight
Component concentration or concentration range
Morpholine
5-7%
CAS No.(CAS110-91-8) 203-815-1
No.)203-815-1
EC-No. 613-028-00-9
Index Numbers
Module 4. First-aid measures

4.1 Description of necessary first aid measures
General recommendations
Consult a physician. Show this safety technical instruction to the physician who arrives at the scene.
Inhalation
If inhaled, move the patient to fresh air. If breathing stops, perform artificial respiration. Consult a physician.
Skin Contact
Remove contaminated clothing and shoes immediately. Rinse with soap and plenty of water. Consult a physician.
Eye contact
Flush thoroughly with plenty of water for at least 15 minutes and consult a physician.
Ingestion
Do not induce vomiting. Do not give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Main symptoms and effects, acute and delayed effects
To the best of our knowledge, the chemical, physical and toxic properties have not been fully studied. (4-(3-HYDROXYPROPYL)MORPHOLINE)
4.3 Instructions and directions for prompt medical treatment and special handling as required
No data available
Module 5. Fire Fighting Measures

5.1 Extinguishing media
Fire extinguishing methods and extinguishing agents
Extinguish the fire with water spray, ethanol-resistant foam, dry powder or carbon dioxide.
5.2 Special hazards originating from the substance or mixture
Carbon oxides, nitrogen oxides
5.3 Advice for firefighters
If necessary, wear a self-contained breathing apparatus to fight the fire.
5.4 Further information
Cool unopened containers with water spray.
Module 6. Emergency response to leaks

6.1 Worker protective measures, protective equipment and emergency response procedures
Use personal protective equipment. Avoid inhalation of vapors, fumes or gases. Ensure adequate ventilation. Remove all sources of ignition.
Evacuate personnel to a safe area. Beware of vapors accumulating to explosive concentrations. Vapors can accumulate in low-lying areas.
6.2 Environmental Protection Measures
If safety can be assured, take measures to prevent further leaks or spills. Do not allow product to enter sewers.
6.3 Reception and removal methods of spilled chemicals and disposal materials used
Containment of the spill, collection of the spill with an anti-electric vacuum cleaner or wet brush, and placement in a container to be disposed of according to local regulations (see Part 13).
See Part 13). Place in a suitable closed container for disposal.
6.4 Refer to other sections
Refer to Section 13 for disposal.
Module 7 Handling and Storage

7.1 Precautions for safe handling
Avoid inhalation of vapors and fumes.
Keep away from sources of ignition. -Smoke and fire are strictly prohibited. Take measures to prevent static build-up.
7.2 Conditions for safe storage, including any incompatibilities
Store in a cool place. Keep containers tightly closed and store in a dry, ventilated place.
Opened containers must be carefully resealed and kept in an upright position to prevent leakage.
7.3 Specific use
No data available
Module 8. Exposure control and individual protection

8.1 Permissible concentrations
Maximum Allowable Concentration
Group Chemical Abstracts Tolerable Concentration Basis
Notation (CAS
No.)
Morpholine110-91-8PC- 60 mg/m3 Occupational Exposure Limits for Hazardous Factors in the Workplace –
TWA Chemical Hazardous Factors
Remarks Skin
PC- 120 mg/m3 Occupational Exposure Limits for Hazardous Factors in the Workplace –
STEL Chemical Hazardous Factors
Contribution of skin contact to exposure
8.2 Exposure control
Appropriate technical controls
Operate in accordance with good industrial hygiene and safety practices. Wash hands before breaks and at the end of work.
Personal protective equipment
Eye/Face Protection
For closely fitted protective eyewear, use equipment tested and approved by official standards such as NIOSH (USA) or EN 166 (EU)
Use equipment tested and approved for eye protection.
Skin protection
Gloves must be inspected before use.
Please remove the gloves in a suitable way (do not touch the external surface of the gloves) and avoid any skin contact with the product.
After use, dispose of contaminated gloves with care in accordance with relevant laws and regulations and valid laboratory procedures. Please wash and dry your hands
The selected protective gloves must comply with the EU regulation 89/686/EEC and the EN 376 standard from which they are derived.
Body protection
The type of protective equipment must be selected according to the concentration and quantity of the hazardous substances in the particular workplace.
Respiratory protection
If the hazard assessment indicates that an air-purifying gas mask is required, use a full-face multi-purpose gas mask (US) or ABEK type
(EN
14387) gas mask cartridges as an alternate for engineering controls. If a gas mask is the only means of protection, use a full facepiece air-supplied gas mask.
Gas masks. Use respirators and parts that have been tested and passed government standards such as NIOSH (US) or CEN (EU).
Module 9. Physical and Chemical Properties

9.1 Information on basic physical and chemical properties
a) Appearance and properties
Shape: Liquid
Color: light yellow
b) Odor
No data available
c) Odor threshold
No data available
d) pH value
No data available
e) Melting point / freezing point
No data available
f) Boiling point, initial boiling point and boiling range
240 – 241 °C – lit.
g) Flash point
85 °C – closed cup
h) Evaporation rate
No data available
i) Flammability (solid, gas)
No data available
j) High/low flammability or explosivity limits No data available
k) Vapor pressure
No data available
l) Vapor Density
No data available
m) Density/relative density
1.049 g/cm3 at 25 °C
n) Water solubility
No data available
o) n-octanol/water partition coefficient
No data available
p) Auto-ignition temperature
No data available
q) Decomposition temperature
No data available
r) Viscosity
No data available
Module 10. Stability and Reactivity

10.1 Reactivity
No data available
10.2 Stability
No data available
10.3 Hazardous Reactions
No data available
10.4 Conditions to be avoided
Heat, flame and sparks.
10.5 Incompatible substances
No data available
10.6 Hazardous decomposition products
Other decomposition products – no data available
Module 11 Toxicological information

11.1 Information on toxicological effects
Acute toxicity
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Skin irritation or corrosion
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Eye irritation or corrosion
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Respiratory or skin irritation
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Mutagenicity of germ cells
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Carcinogenicity
IARC:
3 – Group 3: Not classified as carcinogenic to humans (Morpholine)
Reproductive toxicity
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Specific target organ system toxicity (primary exposure)
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Specific target organ system toxicity (repeated exposure)
No data available
Inhalation hazard
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
Potential Health Effects
May be harmful if inhaled by inhalation. The substance is highly destructive to tissues, mucous membranes and the upper respiratory tract
Ingestion is harmful if taken. Causes burns.
Skin absorption through the skin may be harmful. Causes skin burns.
Causes eye burns.
Signs and symptoms of exposure
To the best of our knowledge, the chemical, physical and toxic properties have not been fully studied. (4-(3-HYDROXYPROPYL)MORPHOLINE)
Additional information
Registration of toxic effects of chemical substances: No data available
Module 12: Ecological information

12.1 Ecotoxicity
No data available
12.2 Persistence and degradability
No data available
12.3 Potential bioaccumulation
No data available
12.4 Mobility in Soil
No data available (4-(3-HYDROXYPROPYL)MORPHOLINE)
12.5 Evaluation of the results for PBT and vPvB
No data available
12.6 Other adverse effects
No data available
Module 13 Waste Disposal

13.1 Waste disposal methods
Product
This explosive product can be burned in a chemical incinerator equipped with post-combustion treatment and scrubbing action
Dispose of the remaining and non-recoverable solution to a licensed company.
Contaminated containers and packaging
Dispose of as unused product.
Module 14. Transport Information

14.1 UN Dangerous Goods Numbers
European Dangerous Goods by Road: – International Dangerous Goods by Sea: – International Dangerous Goods by Air: –
14.2 UN Transport Name
Eurocruise: Non-dangerous goods
International Maritime Dangerous Goods: Non-dangerous goods
International Air Dangerous Goods: Non-dangerous goods
14.3 Transport hazard classes
International Maritime Dangerous Goods: – International Air Dangerous Goods: –
14.4 Parcel groups
Eurocruiser: – International Maritime: – International Air: –
14.5 Environmental hazards
Eurocruiser: No International Maritime Dangerous Goods International Air Dangerous Goods: No
Marine Pollutants (Yes/No): No
14.6 Special reminders for users
No data available

Module 15 – Regulatory Information

N/A

Module 16 – Other Information

N/A
4-(3-Hydroxypropyl)morpholine Toxicity and Ecology
Toxicological data for 4-(3-hydroxypropyl)morpholine:

Acute toxicity: intravenous LD50 in mice: 950 mg/kg.

4-(3-Hydroxypropyl)morpholine Toxicity English version

4-(3-Hydroxypropyl)morpholine Safety Information
Symbol GHS05
GHS05
Signal word Danger
Hazard Statement H314
Warning statement P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Hazard Code (Europe) Xi:Irritant;
Risk statement (Europe) R36/37/38
Safety declaration (Europe) S26-S36
Dangerous Goods Transport Code UN 3267 8 / PGI
WGK Germany 2
RTECS number QE9104700
Customs code 2934999090

Storage and transportation.
Should be sealed and stored in a dry, cool and ventilated warehouse

Package.
200KG/drum Storage: It is recommended to store in dry and cool area with proper ventilation.
Please fasten the lid as soon as possible after the original packaging to prevent the mixing of other substances such as water and other substances from affecting the product performance.
Do not inhale dust and avoid skin and mucous membrane contact. Smoking, eating and drinking are prohibited in the workplace. After work, shower and change clothes.
Store contaminated clothes separately and wash them before use. Maintain good hygiene habits.